In the research project, correlations between the operating behavior of rod seals and wetting characteristics were investigated experimentally. Analytical work carried out includes the determination of the disperse and polar fractions of the surface energy of different oils and sealing ring materials. The friction and wear behavior of rod seals was investigated in test rig trials. The results can be used to evaluate the friction-velocity behavior of the sealing rings as a function of the viscosity of the oils and their wetting properties. The significantly lower frictional force of rod seals lubricated with silicone oil was striking. The wear behavior as a function of the lubricant (e.g. hydraulic oil) was investigated in endurance tests. The lower the polarity and the higher the viscosity of the lubricant, the lower the wear on the sealing ring has turned out to be.